Denne undersøgelse undersøger sammenhængen mellem genetiske varianter i oxytocin-receptorgenet (OXTR) og menneskelig parbinding samt sociale adfærd. Forskning viser, at en bestemt SNP i OXTR er forbundet med parbindingsadfærd hos kvinder og sociale problemer i barndommen, hvilket kan forudsige parbinding senere. Resultaterne antyder, at oxytocins rolle i sociale relationer, som set hos mosegrise, også kan være relevant for mennesker.
Titel på undersøgelse:
Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.
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Hele abstrakt på originalsprog:
This study explored the association between genetic variants in the oxytocin receptor gene (OXTR) and pair-bonding behaviors in humans, drawing parallels to oxytocin’s role in vole and primate bonding. Twelve single nucleotide polymorphisms (SNPs) were genotyped in two Swedish cohorts—the TOSS (n=2309) and TCHAD (n=1240)—using self-reported pair-bonding measures, with further analysis of one SNP (rs7632287) for marital status and quality in TOSS, longitudinal childhood predictors of romantic behavior in TCHAD, and childhood social behaviors in TCHAD and CATSS (n=1771). Results showed rs7632287 was linked to pair-bonding traits in women across TOSS and TCHAD; in girls, it correlated with childhood social problems in TCHAD, predicting later pair-bonding behavior, a finding replicated in CATSS where it was associated with autism spectrum social deficits. These findings suggest OXTR variation influences human pair-bonding and social behaviors, extending oxytocin’s known affiliative role in animals to humans.